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Yale Medicine Thesis Digital Library

Starting with the Yale School of Medicine (YSM) graduating class of 2002, the Cushing/Whitney Medical Library and YSM Office of Student Research have collaborated on the Yale Medicine Thesis Digital Library (YMTDL) project, publishing the digitized full text of medical student theses on the web as a valuable byproduct of Yale student research efforts. The digital thesis deposit has been a graduation requirement since 2006. Starting in 2012, alumni of the Yale School of Medicine were invited to participate in the YMTDL project by granting scanning and hosting permission to the Cushing/Whitney Medical Library, which digitized the Library’s print copy of their thesis or dissertation. A grant from the Arcadia Fund in 2017 provided the means for digitizing over 1,000 additional theses. IF YOU ARE A MEMBER OF THE YALE COMMUNITY AND NEED ACCESS TO A THESIS RESTRICTED TO THE YALE NETWORK, PLEASE MAKE SURE YOUR VPN (VIRTUAL PRIVATE NETWORK) IS ON.

Theses/Dissertations from 2023 2023

Radiomics: A Methodological Guide And Its Applications To Acute Ischemic Stroke , Emily Avery

Characterization Of Cutaneous Immune-Related Adverse Events Due To Immune Checkpoint Inhibitors , Annika Belzer

An Investigation Of Novel Point Of Care 1-Tesla Mri Of Infants’ Brains In The Neonatal Icu , Elisa Rachel Berson

Understanding Perceptions Of New-Onset Type 1 Diabetes Education In A Pediatric Tertiary Care Center , Gabriel BetancurVelez

Effectiveness Of Acitretin For Skin Cancer Prevention In Immunosuppressed And Non-Immunosuppressed Patients , Shaman Bhullar

Adherence To Tumor Board Recommendations In Patients With Hepatocellular Carcinoma , Yueming Cao

Clinical Trials Related To The Spine & Shoulder/elbow: Rates, Predictors, & Reasons For Termination , Dennis Louis Caruana

Improving Delivery Of Immunomodulator Mpla With Biodegradable Nanoparticles , Jungsoo Chang

Sex Differences In Patients With Deep Vein Thrombosis , Shin Mei Chan

Incorporating Genomic Analysis In The Clinical Practice Of Hepatology , David Hun Chung

Emergency Medicine Resident Perceptions Of A Medical Wilderness Adventure Race (medwar) , Lake Crawford

Surgical Outcomes Following Posterior Spinal Fusion For Adolescent Idiopathic Scoliosis , Wyatt Benajmin David

Representing Cells As Sentences Enables Natural Language Processing For Single Cell Transcriptomics , Rahul M. Dhodapkar

Life Vs. Liberty And The Pursuit Of Happiness: Short-Term Involuntary Commitment Laws In All 50 US States , Sofia Dibich

Healthcare Disparities In Preoperative Risk Management For Total Joint Arthroplasty , Chloe Connolly Dlott

Toll-Like Receptors 2/4 Directly Co-Stimulate Arginase-1 Induction Critical For Macrophage-Mediated Renal Tubule Regeneration , Natnael Beyene Doilicho

Associations Of Atopic Dermatitis With Neuropsychiatric Comorbidities , Ryan Fan

International Academic Partnerships In Orthopaedic Surgery , Michael Jesse Flores

Young Adults With Adhd And Their Involvement In Online Communities: A Qualitative Study , Callie Marie Ginapp

Becoming A Doctor, Becoming A Monster: Medical Socialization And Desensitization In Nazi Germany And 21st Century USA , SimoneElise Stern Hasselmo

Comparative Efficacy Of Pharmacological Interventions For Borderline Personality Disorder: A Network Meta-Analysis , Olivia Dixon Herrington

An Examination Of Honor Society Membership, Mistreatment, And Discrimination By Medical Student Demographics , Katherine Ann Hill

Factors Influencing Decision For Contralateral Prophylactic Mastectomy Versus Unilateral Mastectomy , Julian Huang

Beta-Catenin Nuclear Transport In Wnt Signaling: Kap-Beta2/transportin Mediates Nuclear Import Of Beta-Catenin Via A Py-Nls Motif In A Ran Gtpase Dependent Manner , Woong Y. Hwang

Perspectives On Emergency Department-Initiated Buprenorphine Among Clinical Pharmacists , Marissa Justen

Examination For Independent Predictors Of Seasonality Of Birth Across Forty-Nine Low- And Middle-Income Countries: Analyses Of The United States Agency For International Development Demographic And Health Survey Data , Jehanzeb Kayani

Pediatricians, Social Identity, And The Law In The Early-Twentieth-Century United States , Christopher R. Keys

Single Neuronal Firing Dynamics In A Mouse Model For Absence Seizures , Waleed Khan

The Impact Of Cannabidiol In Patients With Early Psychosis: A Randomized Controlled Trial , Sreeja Kodali

Renalase Agonist Therapy And The Cardiac Response To Pressure Overload In Chronic Kidney Disease , Govind Krishna Kumar Nair

Sociodemographic And Insurance Disparities In Urologic Oncology Care Access And Surgical Outcomes , Folawiyo Laditi

How Ethics Committees Deliberate Resource Allocation For Undocumented Children, A Qualitative Analysis , YuKyung Lee

Mental Health Service Use Among Immigrant And U.S. Born Asian American Pacific Islanders , Hieronimus Loho

Severity And Operative Age In Metopic Synostosis: The Association With Neurocognitive Outcomes , Aaron Samuel Long

Comparison Of The Bone Bruise Patterns In Contact And Non-Contact Acute Anterior Cruciate Ligament Injuries , Jay Thomas Moran

Multi-Omic Differences Between Right And Left Sided Colorectal Cancer Liver Metastases , Montana Tremaine Morris

Almajiri Health; A Scoping Review On Disease, Health Literacy And Space For Participatory Research , Muzzammil Imran Muhammad

Investigating Effects Of Glycolysis Inhibition On Metabolism And Extracellular Ph In A Mouse Model Of Hepatocellular Carcinoma , David Nam

Applying Deep Learning To Identify Imaging Biomarkers To Predict Cardiac Outcomes In Cancer Patients , Aishwarya Kishore Nene

Incarcerated Patients Have Higher Mortality After Trauma: An Unreported Healthcare Disparity , Harry NewmanPlotnick

The Association Between Social Needs Care Coordination And Social Needs Status Amongst Patients In A Federally Qualified Health Center , Autumn Nobles

Diagnosis Of Polycystic Ovary Syndrome And Non-Hispanic Black Race Are Predictive Of Hypertension In Reproductive Age Women -Analysis Of Real World Electronic Medical Record Data , Nyerovwo Okifo

Utility Of Shear Wave Elastography In Breast Cancer Diagnosis: A Systematic Review And Meta-Analysis , Aishwarya Pillai

“I Was Reaching Out For Help And They Did Not Help Me”: Mental Healthcare In The Carceral State , Anna Grace Preston

Associations Of Frailty With Tumor Characteristics & Longitudinal Outcomes In Patients With Meningiomas , Hanya M. Qureshi

A Single Nucleotide Polymorphism In An Rgs6 Enhancer Regulates Heart Rate Variability And Parasympathetic Modulation , Namita Ravi

Firearm Injury Prevention Strategies In Children And Young Adults , Christopher Schenck

Assessing Quality Of Oral Cancer Care Across A Health System And Region: Opportunities To Improve Care , Hemali Parimal Shah

Single-Cell Transcriptomic Atlas Reveals Molecular Drivers Of Human Inner Ear Development , Amar H. Sheth

More Than Meets The Eye: Improving Recognition Of Child Abuse In Emergency Departments , May Shum

A Novel Smarcc1-Mutant Bafopathy Implicates Epigenetic Dysregulation Of Fetal Neural Progenitors In The Pathogenesis Of Congenital Hydrocephalus , Amrita K. Singh

Baseline Skin Cytokine Profiles Determined By Rna In Situ Hybridization Correlate With Response To Dupilumab In Patients With Eczematous Dermatitis , Katelyn Singh

Barriers To Identifying Learning Disabilities: A Qualitative Study Of Clinicians And Educators , Lauren Stone

"Come On. I Need An Answer." A Mixed-Methods Study Of Barriers And Disparities In Diagnostic Odysseys , Zeyu Tang

Cognitive Impairment And Long-Term Health Outcomes In Patients With Coronary Microvascular Dysfunction , Abriana Tasillo

Family Dyads, Emotional Labor, And The Theater Of The Clinical Encounter: Co-Constructive Patient Simulation As A Reflective Tool In Child And Adolescent Psychiatry Training , Isaiah Thomas

Comparative Effectiveness Of Digital Breast Tomosynthesis For Breast Cancer Screening In Older Women , Akhil Upneja

Analysis Of Prices And Outcomes For Common Hospitalized Conditions In 2021 , Lina Vadlamani

Recording Multiunit Activity Of The Locus Coeruleus In An Awake Mouse Model Of Focal Limbic Seizures , Marcus Valcarce-Aspegren

Improving Cancer Classification With Domain Adaptation Techniques , Juliana Veira

Soil-Transmitted Helminthiases And Deworming Response In School-Aged Children In Retalhuleu, Guatemala , Rebeca Esther Vergara Greeno

The Synergy Between Physiologic Dendritic Cells And Mrna-Loaded Lipid Nanoparticles And Its Potential As A Cellular Immunotherapy , Brian Myles Wei

Lipid Profiles Help Explain Protection From Atherosclerosis In Ascending Aortic Aneurysm Patients , Gabe Weininger

The Impact Of Peer Interventions On Physical Activity For Individuals Living With Mental Illness , Julia Wolfe

Perioperative Outcomes In Patients With Systemic Sclerosis: An Analysis Of A Large Case Series , Luying Yan

Engineering And Evaluating Biodegradable Bioadhesive Nanoparticle-Encapsulated Sunscreens , Beverly Xi Yu

Theses/Dissertations from 2022 2022

Contested Spaces, Stigmatized Treatment: Methadone In 1970s New York, Boston, And New Orleans , Zoe Miranda Adams

Comorbid Pad And Mvd: A Retrospective Nrd Analysis Of Trends, Outcomes, And Readmissions , Miguel Algara

Epidemiology Of Domestic Violence-Related Ocular Injuries Among Adult Patients , Joana E. Andoh

Longitudinal Modeling Of Early Hiv Burden In The Central Nervous System , Victor Diego Armengol

Generating Clinical Evidence Using Real World Data And Personal Digital Devices , Victoria L. Bartlett

Incidence And Prognosis Of Cranial Neuropathies In Children With Covid-19: A Systematic Review And Meta-Analysis , Priyanka Bisarya

A Deep Dive In Head & Neck Cancer: Machine Learning Applications In Diagnostic And Prognostic Evaluations , Alexandra Tan Bourdillon

A Serological Survey Of Sars-Cov-2 Infection In Casino Employees , Julian Campillo Luna

The Real Cause Of The Broken Rib: Developments In Pediatricians' Approach To Child Abuse; 1960 - 2020 , Sofia Charania

Identification Of A Novel Link Between Adiposity And Visuospatial Ability , Herbert Alexander Chen

Predictors Of Very Late Onset Infection In Kidney Transplant Recipients At Least Ten Years Post Transplant , Harry Cheung

Deep Learning Algorithms For Predicting Response To Neoadjuvant Chemotherapy For Breast Cancer , Rachel Choi

Testing Ictal Conscious Awareness: Responsiveness Versus Recall Of Experiences During Seizures , Violeta Contreras Ramirez

Mechanisms Of Progestin Resistance In Reproductive-Age Women With Atypical Endometrial Hyperplasia , Katherine Mcmaster Cooke

Biomarkers Of Egfr Decline After Pediatric Cardiac Surgery In The Assess-Aki Cohort , Christina Anne-Josiane De Fontnouvelle

Amd3100 Administration For The Treatment Of Asherman’s Syndrome In A Murine Model , Pablo Antonio Delis

Fracture Callus Evaluation In The Setting Of Breast Cancer Metastasis And Rescue Of Healing Via Inhibition Of Erk1/2 , Christopher Dussik

Primary Care Characteristics And Medication Management Among Patients Receiving Office Based Opioid Treatment With Buprenorphine , Xinxin Du

Factors Impacting Trauma-Specific Quality Of Life Following Injury: A Multi-Center Assessment In Lebanon , Ali Elreichouni

Consciousness: Mechanisms And Neuropsychiatric Outcomes , Isaac Gilbert Freedman

Investigation Of Outcomes Following Cervical Spine Surgery In Patients With Pre-Existing Non-Spinal Neurological Conditions , Anoop Raj Galivanche

Medical Students’ Experiences, Knowledge, And Perceptions Of Patients With Substance Use Disorder , Sophia Francesca Gamez

“people Fall Through The Cracks”: Prolonged Lengths Of Stay Beyond Medical Necessity , Lucy Gao

Housing As Healthcare: The Role Of Homelessness In Patient Characteristics And Retention In Outpatient Medication For Opioid Use Disorder Treatment , Marina Gaeta Gazzola

Sleep Apnea In Veterans With Schizophrenia: Estimating Prevalence And Impact On Cognition , Stephen Edward Ghazikhanian

Self-Injurious Behavior And Problematic Video Gaming In Adolescents With Problematic Shopping , Norman Robert Greenberg

Importance Of Social Support In Older Adults After Hospitalization For Acute Myocardial Infarction , Yaakov Green

In-Vivo Nanoparticle Delivery To Fetal Mouse Pancreas And Liver , Mary Elizabeth Guerra

Characteristics Of Inpatient Behavioral Health Services And Hormonal Treatment Decision-Making In Transgender/gender-Expansive Youth , Justin William Halloran

Preferential Utilization Of Resident Physicians To Care For Patients With Medicaid And Persons Of Color At Us Academic Health Centers , Samer Hassan

Atypical Presentation Of Hereditary Hypophosphatemic Rickets With Hypercalciuria Due To Digenic Mutations , Bryan Bo-Ran Ho

Gender Differences In Outcomes Of Coordinated Specialty Care For Early Psychosis , Seong Im Hong

Resident Physician Thriving And The Residency Experience During The Covid-19 Pandemic: A Qualitative Study , Joshua Hyman

Early Experience With The Fda’s Breakthrough Devices Program And Potential Payment Mechanisms , James Johnston

Page 1 of 31

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Home > FACULTIES > Pathology > PATHOL-ETD

Pathology and Laboratory Medicine Department

Pathology Theses and Dissertations

This collection contains theses and dissertations from the Department of Pathology, collected from the Scholarship@Western Electronic Thesis and Dissertation Repository

Theses/Dissertations from 2023 2023

Investigation of Novel Pan-RAF Inhibitors in Anaplastic Thyroid Cancer , Sarah EB Ryan

Theses/Dissertations from 2022 2022

Evaluating the utility of S100A7 in identifying oral dysplastic lesions that will progress to oral squamous cell carcinoma , Jeff Soparlo

Theses/Dissertations from 2021 2021

Investigating The Impact Of The COVID-19 Pandemic On Maternal Perceived Stress, Postpartum Depressive Symptoms, And Pregnancy Outcomes In London, Ontario: A One Health Approach , Mei Yuan

Theses/Dissertations from 2020 2020

Evidence of an Antigen Presenting Cell Phenotype in Granular Cell Tumours , Benjamin J W A Rogala

Theses/Dissertations from 2019 2019

Junctophilin-2 Protects Cardiomyocytes against Palmitate-induced Injury , Xiaoyun Ji

Evaluating the Utility of Protein Biomarker, S100A7, and Diagnostic Test, Straticyte, in Predicting the Progression of Oral Dysplasia , Lachlan McLean

Alpha-Synuclein Toxicity is Caused by Mitochondrial Dysfunction , Michael G. Tauro

Theses/Dissertations from 2018 2018

Non-Cancerous Abnormalities That Could Mimic Prostate Cancer Like Signal in Multi-Parametric MRI Images , Mena Gaed

Mitochondrial permeability regulates cardiac endothelial cell necroptosis and cardiac allograft rejection , Ingrid Gan

Kallikrein-Related Peptidases are Dysregulated in Pleomorphic Adenoma , Matthew D. Morrison

Increased Mitochondrial Calpain-1 Is an Important Mechanism Contributing to Mitochondrial ROS Generation in Cardiac Diseases , Rui Ni

Elucidating mechanisms of innate and acquired resistance to PI3Ka inhibition in head and neck squamous cell carcinoma , Kara M. Ruicci

The Effects of Child Restraint System Use and Motor Vehicle Collision Severity on Injury Patterns and Severity in Children 8 Years Old and Younger. , Peyton A. Schroeder

Role of Long Noncoding RNAs in Diabetic Complications , Anu Alice Thomas

Effect of Estrogen and Glucocorticoid Signaling on Th2 cells – Implications for Severe Asthma , Meerah Vijeyakumaran

Theses/Dissertations from 2017 2017

CRISPR Screen for Identification of Kinases that Mediate Prostate Cancer Cell Invasion , Hamad Aldhafeeri

Immunological Impact of CLI-095 on Dendritic Cell Maturation and Hypoxia-re-oxygenation induced inflammatory injury , Hajed Obaid Alharbi

ERK5 Expression in Brain Tumours , Reem Ansari

Expression of Human Tissue Kallikreins (KLKs) in Polymorphous Low Grade Adenocarcinoma (PLGA) , Jacqueline M. Cox

A Clinico-Pathological Study of the Structural and Functional Changes in the Retina and Optic Nerve Following Diabetic Retinopathy Treatments , Richard Filek

Mechanisms underlying chemotherapy-induced vascular proliferation in ovarian cancer , Zeynep Gülsüm Kahramanoğlu

The Effect of Glucocorticosteroids on Th2 cells , Tharsan Kanagalingam

Hsp90 and its Co-chaperones Modify TDP-43 Localization, Aggregation, and Toxicity , Lilian T. Lin

Characterization of Hemangioma-initiating Stem Cells , Natalie Montwill

Postnatal β1 Integrin Deficiency in Pancreatic Beta-Cells Impairs Function and Survival , Jason E. Peart

Up-regulation of junctophilin-2 prevents ER stress and apoptosis in hypoxia/reoxygenation-stimulated H9c2 cells , Zijun Su

Theses/Dissertations from 2016 2016

Body and Organ Measurements in Infants and Neonates: An Autopsy Study , Audrey-Ann M. Evetts

The Long Non-coding RNA Malat1 Regulates Inflammatory Cytokine Production in Chronic Diabetic Complications , Andrew D. Gordon

Expression of Kallikrein-Related Peptidases (KLKs) in Adenoid Cystic Carcinoma , Zachary R. Kerr

Mechanisms regulating stem cell phenotype in infantile hemangioma , Niamh Richmond

Etiology of Motor Vehicle Collision Fatalities in Urban and Rural Canada , James R. Roos

Identification of a Nuclear Localization Signal (NLS) within the Pleckstrin Homology (PH) domain of Rho Guanine Nucleotide Exchange Factor (RGNEF) , Michael V. Tavolieri

Development and Performance Evaluation of an Antibody-Based Technology for Detection of E. coli O157 in Meat Samples and Its Potential Evolution Using Antibody Engineering , Yadira Tejeda Saldaña

Regulation of Phosphatase and Tensin Homolog Expression and Activity by Transforming Growth-Factor Beta in the Trabecular Meshwork Cells: Implications for Primary Open Angle Glaucoma , Nikoleta Tellios

Theses/Dissertations from 2015 2015

Phase II Clinical Trial of Concurrent Neoadjuvant Chemotherapy With Radiotherapy in Locally Advanced Breast Cancer , Muriel Brackstone

Expression Of Human Kallikrein Protein And mRNA In Maxillofacial Cysts And Tumours , Karl Kevin Cuddy

Chromatin Structure and Differential Accessibility of Homologous Human Mitotic Metaphase Chromosomes , Wahab A. Khan

β-adrenergic receptor-dependent and -independent effects of propranolol in infantile hemangioma , Jina J.Y. Kum

CD4+ T-cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection Involves Necroptosis , Cecilia YT Kwok

Epithelial to mesenchymal transition in the metastatic progression of gastroenteropancreatic neuroendocrine tumours , Stephanie Mok

Protective Effect of Modified Human Fibroblast Growth Factor on Diabetic Nephropathy , Ana M. Pena Diaz

Diabetic Bone Marrow & Stem Cell Dysfunction , Meghan A. Piccinin

Investigation of Pancreatic β-Cell Insulin Receptor Regulation of β-Cell Growth, Function, and Survival Via a Temporal Conditional Knockout , Liangyi Zhou

Theses/Dissertations from 2014 2014

The Role Of The RNA-Binding Protein Rho Guanine Nucleotide Exchange Factor In The Cellular Stress Response , Kevin WH Cheung

Exposure to Environmental Contaminants and Stress as Determinants of Health in Three Communities: Walpole Island and Attawapiskat First Nations and Naivasha, Kenya , Deirdre Phaedra Henley

miRNA Regulation of Programmed Cell Death-1 in T Cells: Potential Prognostic and Therapeutic Markers in Melanoma , Nathan J. Johnston

Cell Death Regulates Injury and Inflammation During Renal Allograft Transplantation , Arthur Lau

Role of SIRT1 in Vascular Complications of Diabetes , Rokhsana Mortuza

RIPK3 Regulates Microvascular Endothelial Cell Necroptosis and Cardiac Allograft Rejection , Alexander William Pavlosky

The Role of Integrins in Support of Pancreatic Function, Survival and Maturation , Matthew Riopel

Polycomb Repressive Complex 2 Regulates miR-200b in Retinal Endothelial Cells: Possible Implications in Diabetic Retinopathy , Michael A. Ruiz

Association of Head and Cervical Injuries in Pediatric Occupants Involved in Motor Vehicle Collisions , Shayan Shekari

Development of Non-Covalent Functionalization of Carbon Nanotubes for siRNA Delivery , King Sun Siu

The Expression and Potential Significance of Human Kallikreins 6, 7, 8, 10, 13, and 14 in the Epithelium of Selected Odontogenic Cysts and Tumors of Variably Aggressive Biological Behaviour , Rebecca Woodford

Theses/Dissertations from 2013 2013

Targeted siRNA Delivery Methods for RNAi-Based Therapies , Di Chen

Elucidating the Role of Menin During Islet Cell Development in the Human Fetal Pancreas , Jessica L. Dubrick

Vascular Stem Cells in Diabetic Complications , Emily C. Keats

Theses/Dissertations from 2012 2012

Immunohistochemical Studies of Expression and Correlation of Osteopontin, CD44, and Integrin αVβ3 in Selected Benign and Malignant Salivary Gland Tumours , Tommy Fok

The role of non-canonical Wnt/planar cell polarity signalling in breast cancer progression , Connor D. MacMillan

Elucidating the Function of Transplanted Islets of Langerhans and Predicting Their Ability to Reverse Diabetes , Andrew R. Pepper

Role of ERK5 in Diabetic Vascular Complications , Yuexiu Wu

Regulation of NK cell-mediated tubular epithelial cell death and kidney ischemia-reperfusion injury by the NKR-P1B receptor and Clr-b , James Yip

Theses/Dissertations from 2011 2011

A Model System for Rapid Identification and Functional Testing of Genes Involved in Early Breast Cancer Progression , Lesley H. Souter

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Addis Ababa University College of Health Sciences School of Allied Health Sciences Department of Medical Laboratory Sciences

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Related Papers

International journal of biological and medical research

Abraham Aseffa

Blood stream infections are major cause of morbidity and mortality in children in developing countries. The emerging of causative agents and resistance to various antimicrobial agents are increased from time to time. The main aim of this study was to determine the bacterial agents and antimicrobial susceptibility patterns among children suspected of having septicemia. A cross sectional study involved about 201 pediatric patients (≤ 12 years) was conducted from October 2011 to February 2012 at pediatric units of TikurAnbessa Specialized Hospital and Yekatit 12 Hospital. Standard procedure was followed for blood sample collection, isolate identifications and antimicrobial susceptibility testing. Among 201 study subjects 110 (54.7%) were males. Majority 147 (73.1%) of them were neonates (≤ 28 days). The mean length of hospital stay before sampling was 4.29 days. Out of the 201 tested blood samples, blood cultures were positive in 56 (27.9%).Gram negative and Gram positive bacteria cons...

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Background. Urinary tract infection (UTI) is considered as the most common bacterial infection seen among the pediatric patients. Objective. This study was carried out in order to determine the prevalence of urinary tract infection in pediatric patients, identify bacterial uropathogens responsible for the infection, and study the antibiotic sensitivity patterns of bacterial isolates. Materials and Methods. A cross-sectional study designed and conducted from January to April 2014. Clean-voided midstream urine specimens were obtained from 384 pediatric patients less than or equal to 15 years in sterile universal bottles. Urine collected from each patient was inoculated onto CLED and blood agar plates using a calibrated inoculating loop with a capacity of 0.001 ml. Inoculated plates were incubated for 24–48 hours at 37°C at inverted position aerobically. Bacterial isolates were indentified and characterized by Gram stain and by using an array of standard routine biochemical tests. The ...

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Background. Enterococcus species, which is previously considered as medically not important, now becomes one of the leading causes of nosocomial infections. Even though it becomes the most public health concern and emerging multidrug-resistant pathogen, there is no enough data in the study area. Objective. To determine the prevalence, antimicrobial resistance pattern, and associated risk factors of enterococci infection in pediatric patients. Methods. A hospital-based cross-sectional study was conducted from February to May 2019 at Dessie Referral Hospital, Northeastern Ethiopia. A total of 403 pediatric patients were included in the study, and a pretested structured questionnaire was used to collect sociodemographic and risk factor-related data. Clinical samples such as urine, blood, wound swabs, discharges, and other body fluids were collected aseptically and inoculated on to Bile Esculin Azide Agar, and colony characteristics, Gram stain, catalase, salt, and temperature tolerance...

Melese Reta

Introduction. e burden of bloodstream infections (BSIs) has been warranted in Ethiopia. Globally, the emergency and raised resistance rate of bacterial antimicrobial resistance is becoming a prominent problem, and it is difficult to treat patients having sepsis. In this review, we aimed to determine the pooled prevalence of bacterial isolates among pre-sumptive patients with bloodstream infections in Ethiopia. Methods. A systematic search was performed from PubMed/ MEDLINE, Scopus, HINARI, ScienceDirect, and Google Scholar electronic databases using PRISMA guidelines. e data analysis was carried out using STATA TM version 14 after the records were cleaned and sorted out. Results. A total of 26 studies with 8,958 blood specimens and 2,382 culture-positive bacterial isolates were included for systematic review and meta-analysis. e meta-analysis derived a pooled culture-positive bacterial prevalence which was 25.78% (95% CI: 21.55-30.01%). e estimated pooled prevalence of Gram-positive and Gram-negative bacterial isolates was 15.50% (95% CI: 12.84-18.15%) and 10.48 % (95% CI: 8.32-12.63%), respectively. e two common Gram-positive bacteria isolated from patients suspected of BSIs were coagulase-negative Staphylococcus with a pooled prevalence of 5.75% (95% CI: 4.58-6.92%) and S. aureus 7.04 % (95% CI: 5.37-8.72%). Similarly, the common Gram-negative bacterial isolates and their estimated pooled prevalence were E. coli 1.69% (95% CI: 1.21-2.16%), Klebsiella species 7.04 % (95% CI: 5.37-8.72%), Pseudomonas species 0.39% (95% CI: 0.08-0.70%), Salmonella species 1.09% (95% CI: 0.79-1.38%), and Streptococcus pyogenes 0.88% (95% CI: 0.54-1.22%). Conclusion. e prevalence of bacterial isolates among presumptive patients suspected to BSIs in Ethiopia remains high. Furthermore, we found a remarkable variation in the pathogen distribution across the study setting.

Workeabeba Abebe

Open Forum Infectious Diseases

tsegaye hailu

Background Community-acquired pneumonia (CAP) remains a leading cause of morbidity and mortality. We sought to determine the magnitude, etiology, and risk factors of CAP in children 5 years after introduction of pneumococcal conjugate vaccine (PCV) 10 in Ethiopia. Methods We conducted a prospective observational study on the bacterial etiology and risk factors of CAP among children aged 0–15 years in 2 pediatric emergency departments in Addis Ababa, Ethiopia. Blood culture, antibiotic susceptibility testing, and amplification of pneumococcal lytA and cpsB genes were performed. Serotypes of Streptococcus pneumoniae were determined by Quellung reaction and sequencing the cpsB gene. Results Out of 643 eligible children, 549 were enrolled. The prevalence of bacteremic pneumonia was 5.6%. Staphylococcus aureus (26.5%) was the predominant pathogenic species, followed by Enterococcus faecium (11.8%), Escherichia coli (11.8%), and Klebsiella pneumoniae (11.8%). In univariate analysis, paren...

Scandinavian Journal of Infectious Diseases

Katharina Olsen

Biruk Yeshitela

Background: Pediatric patients are at increased risk of nosocomial infections with multi-drug resistant pathogens which are more prevalent in the hospital environment. The aim of this study was to determine the prevalence of nosocomial infections, antibiotic resistance pattern of bacterial isolates and associated factors in pediatric patients. Methods: This was a cross-sectional study conducted from March to August, 2016. Data included sociodemographic and clinical variables in patients clinically suspected of having nosocomial infections and collected using a structured questionnaire. Bacterial identification and antimicrobial susceptibility test was done with standard microbiological methods. Data were analyzed with SPSS version 20 and p value < 0.05 was considered to be statistically significant. Results: Out of 939 children admitted to the hospital, 384 patients (40.9%) were clinically suspected and had 462 nosocomial infections. Blood stream infection was the most common site of nosocomial infections. Culture confirmed nosocomial infections were reported in 82 patients (21.4%; 95% CI, 17.2-25.8%) with 88 isolates. Among the most frequently isolated bacteria, 21 (23.9%) were Klebsiella spp, and 16 (18.2%) were S. aureus, 62.5% of which were methicillin resistant. Among all bacterial pathogens, 88.9% were multi-drug resistant. Extremely high (97.9%) multi-drug resistance was associated with Gram negative bacteria. Among these, all isolates, except E. coli, were 100% multi-drug resistant. Long hospital stay and malnutrition were significantly associated with nosocomial infections. Conclusion: The high prevalence of nosocomial infections with multi-drug resistant bacteria suggests the need for proper implementation of the nosocomial infections prevention and control measures.

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Background. The spectrums of infections due to methicillin-resistant Staphylococcus aureus are manifold and are associated with worse outcomes. A study on the prevalence of these pathogens and their sensitivity patterns will give updated information which is very helpful for health personnel responsible in the management of patients and timely monitoring of the emergence of resistant bacteria. Hence, the study aimed at assessing the prevalence of methicillin-resistant Staphylococcus aureus and associated factors among patients with wound infection at Dessie Referral Hospital. Method. A cross-sectional study was conducted among 266 patients at Dessie Referral Hospital from February to May 2016. Wound swab samples were collected aseptically using Levine’s technique and transported to Dessie Regional Laboratory by using brain-heart infusion transport media. Isolation of Staphylococcus aureus was done based on cultural and biochemical profiles. Drug susceptibility test was performed usi...


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  • v.38(3); 2017 Nov

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Enhancing the Clinical Value of Medical Laboratory Testing

The value of medical laboratory testing is often directed to the cost of testing however the clinical benefits of these tests are at least as important. Laboratory testing has an acknowledged widespread role in clinical decision making, and therefore a role in determining clinical outcome. Consequently, the value of laboratory testing should be considered in its role in affecting beneficial actions and outcomes. This includes both the requesting phase of choosing tests which will influence clinical decision making as well as the reporting phase in a way that guides clinical decisions and actions. Clinical decision support systems and software can enhance the value of medical laboratory testing if they are directed toward facilitating those clinical decisions where there is either evidence, or agreed consensus, addressing patient outcomes.


Value is often expressed in terms of “quality, clinical efficacy and effectiveness, patient centre-edness, patient satisfaction, timeliness, clinical efficiency, cost effectiveness, productivity affordability and cost”. 1 Laboratory value should ideally be judged in a manner consistent with the main goals of a health system which include disease prevention, early detection, establishing an accurate diagnosis, selecting the right treatment, avoiding delays in treatment, facilitating recovery, reducing disability, preventing relapse or retarding disease progression and reducing the need for long term care. 2 Since laboratory testing can help to guide each of these clinical decision points, 3 these health goals are also the primary goals of laboratory testing.

The often stated claim that 70% of clinical decisions depend on laboratory testing may have been established on little evidence, 4 but the claim is supported by recent surveys of specialist clinicians in Germany and the USA which found 60–70% of clinical decisions were affected by laboratory test results, both in the hospital setting and outside. 5 Furthermore, surveys of evidence based clinical guidelines show that at least 80% of guidelines which are aimed at establishing a diagnosis or managing disease require laboratory testing. 3

The funding of laboratory medicine is typically focused on the cost of testing rather than the clinical value of testing. 6 Laboratory specialists may be entitled to be cynical about cost surveys of laboratory testing because, in the words of Oscar Wilde, a cynic is someone who knows the price of everything and the value of nothing. 7

Defining the Value of Medical Laboratory Testing

Whilst value can be defined as ‘the importance, worth or usefulness or something’, cost is a simple definition and simply ‘the amount that has to be paid for something’. The dependence between cost and value involves the benefit of the product; therefore a cost-benefit relationship can be defined as the amount that has to be paid to gain a financial benefit or ‘profit’ or alternatively a non-financial benefit or one that is difficult to define in purely financial terms, such as ‘quality of life’. Since the goals of healthcare are ultimately defined in improving health outcome, the simplest definition of value in healthcare is ‘health outcome achieved per dollar spent’. 8 I would note that the comparison of health outcome to cost asks us to put a dollar value on someone else’s life and wellbeing, which is at least as problematic as putting a dollar value on your own. It may be appropriate to compare the costs and health outcomes separately, such as (a) the health outcomes associated with obtaining healthcare against the health outcomes when not obtaining that care, and/or (b) the cost of obtaining healthcare against the costs of not obtaining that care. We would then still have the ethical challenges inherent in matching outcome differences with the cost differences. 9

While the value of medical laboratory testing could be regarded as the health benefit compared to cost, we should not neglect the supportive factors for benefit which include technical quality and timeliness. 5 Recent hospital accreditation standards focus heavily on turnaround times for all pathology disciplines in order to reduce length of stay. 10 While we are told, “time is money”, the benefits of efficiency include not only reduced costs but also earlier treatment and therefore improved clinical outcomes. While economic measures such as cost of laboratory testing can be added to the cost of an episode of care, the trade-off between these costs and improved health benefits is much harder to define. Analytical quality (precision and trueness) must also be considered in essential prerequisites of laboratory test value, however the clinical impact of those tests to reflect health and disease (specificity and sensitivity) are better measures of clinical utility. 2

The International Federation of Clinical Chemistry (IFCC) co-sponsored a meeting of world experts in Stockholm during 1999 which aimed at identifying the various strategies used to define quality in laboratory medicine, but also to develop a hierarchy which lists and ranks the preferred strategies for determining quality. 11 The agreed five level hierarchy has since been applied, for example to set allowable quality limits for analytical performance for external quality assurance (proficiency testing). 12 However the hierarchy was rarely applied to non-analytical areas of laboratory quality 13 perhaps suggesting the hierarchy may have been too complex to apply routinely. Fifteen years after the Stockholm meeting, a similar group of experts met in Milan during 2014 and together agreed to simplify the number of levels in the hierarchy from five to three; (a) quality based on clinical outcomes, (b) quality based on biological variation and lastly (c) quality based on state of the art. 14 The Milan meeting also hoped this simplified system would facilitate the broader consideration of laboratory quality beyond the analytical phase, drawing attention to the critical phases before analysis (i.e. test selection and sample processing) 15 as well as those after analysis (i.e. interpretation and clinical action). 16 While the focus of laboratory for many years has been improving analytical quality, Plebani and his co-workers have established that most errors occur in the extra-analytical phases. 17

Clinical Wisdom

According to Berte & Nevalainen, the potential impact of laboratory tests on clinical outcome can be summarised in a sequence of three questions: 18

  • Does a laboratory test change the way a clinician thinks about a patient? Then if so:
  • Does that change in thinking alter the way the clinician manages the patient? Then if so:
  • Does that change in patient management affect clinical outcome (i.e. mortality/morbidity)?

With increasing access to computerised health data, clinicians face a modern challenge in knowing what to do with all this information. Zelany was one of the first to try and define the stages of modern informatics starting from ‘knowing nothing’, and progressing through ‘knowing what it is’, ‘how it happened’, ‘why it is important’ and concluding with ‘what is the best thing to do in response to that importance’. 19 In simpler words; ‘Know Nothing’, ‘Know What’, ‘Know How’, ‘Know Why’, ‘Know Best’. Even in earlier times, author T.S. Eliot may have understood this sequence of importance and relevance when he wrote:

  • Where is the Life we have lost in living?
  • Where is the wisdom we have lost in knowledge?
  • Where is the knowledge we have lost in information? 20

This philosophy of the value of data and information is commonly referred to as the ‘Data-Information-Knowledge-Wisdom (DIKW) framework’ and it is becoming popular across the expanding science of ‘Informatics’ including the sub-discipline of ‘Health Informatics’.

The DIKW framework can be directly applied to the process of interpreting laboratory test results:

Prior to interpretation, a clinician’s initial thoughts are to choose suitable laboratory tests and once the report is received, to think about the clinical significance of the results of those chosen tests. The clinicians ‘Brain to Brain Loop’ was initially defined by Lundberg. 22 More recently Lundberg together with Plebani and Laposata, have reminded us that there are at least two other ‘brains’ that might facilitate the value of laboratory testing i.e. the laboratorian’s brain and the patient’s brain. 23 The laboratorian can assist with appropriate test requesting and interpreting reports. The patient has the ultimate motivation in considering and agreeing to have the tests done in the first place, as well as considering and agreeing to any clinical management consequently indicated by the results of testing.

Patients are often the prime motivators of laboratory testing and have expectations that laboratory testing will relieve (or realise) their anxieties about underlying illness. When clinicians are unsure about the guidelines for screening, it is very likely that patient anxiety or expectation will increase the likelihood of patients being tested regardless of guidelines. 24 General practitioners will admit that the perceived need of the patient for reassurance through testing is seen as an easy, cost- and time-effective strategy during consultation. 25 , 26

The frequency that general practitioners request laboratory tests varies by geographic location, and may be determined by practitioner availability in that area. 27 While the largest variations in requesting are seen with rarely requested tests, 28 common test request rates can also vary by geography: Prostate Specific Antigen (PSA) testing (which is controversial and a cause of patient anxiety) shows large variation in use by geographic location. 29 Variation of clinical behaviour may also reflect differences or gaps in understanding 30 therefore studies on the regional use of laboratory tests potentially provide an excellent base for educational initiatives. 31 Other studies have also found that requesting behaviour is related to clinician experience but not significantly affected clinicians medico-legal attitude to risk taking. 32

There have been numerous strategies proposed to influence laboratory test utilisation. 33 These can be categorised as either (a) restricting access to testing, (b) feedback on the level of testing and/or (c) education regarding guidelines for appropriate testing. On their own, educational programs are generally more effective than a feedback strategy, 34 while restricting access to testing will have various degrees of success depending on the degree of the restriction of access. These strategies are more effective when combined. Conversely, easy access to a bank of tests (test profiles), often defined by laboratories, may have a large effect on regional test use. 35 It is important to note that the incremental cost of some routine tests can be so small, that a restriction in the number of tests per request may not lead to a significant change in the overall cost of testing. 36

Test request influencing strategies are based on the assumption that it is possible to define inappropriate utilisation. With increasing use of laboratory tests since the 1990s, there has been an accompanying exponential increase in the number of published articles auditing test utilisation. 37 Contrary to the widespread expectation that overutilisation is the main problem, a meta-analysis found that 45% of studies found evidence of under-utilisation whereas only 21% found evidence of overutilisation. 38 An example of underutilisation includes lack of diabetes follow-up with HbA1c and urine albumin. The published basis for judging appropriateness of laboratory testing has also shifted from the each author’s opinion on what can be defined as appropriate use, to the use of clinical or organisational guidelines as the basis for defining appropriate test use. 38 It is important to note that many clinical guidelines are based on the subjective consensus of chosen experts rather than truly objective evidence. Achieving consensus on what is an appropriate test request is a significant barrier to improving test utilisation. 39 When test requesting by general practitioners is surveyed and compared to what clinical guidelines would mandate, most general practitioner test requests are not compliant and the main difference is adding other tests not specified in the guidelines. 40 , 41

Quality Framework Applied to Extra-analytical Phases of Laboratory Testing

The Table applies the three ‘Milan’ strategies of defining analytical quality (clinical outcome/biological variation/state of the art) to the extra-analytical phases of laboratory testing.

The Milan hierarchy for analytical quality reconsidered in terms of all phases of laboratory testing.

The baseline for assessing quality is the ‘State of the Art’, where a peer based approach describes the status quo and should be considered the minimum standard of care. Indeed, the medico-legal standard of appropriate care is often defined as following what the ‘reasonable’ practitioner would do in the same clinical circumstance. We generally accept (and hope) that the majority of medical practitioners are reasonable, and the commonest practices are the safest.

The second ‘biological variation’ strategy is a concept that simply states that ‘the allowable analytical variation is less than half the day to day intra-individual biological variation of the patient’. In other words, that the inevitable analytical noise seen during measurement is less than the biological signals we are trying to assess in each patient. If analytical noise is too great, the changes in laboratory results will be mainly due to what is happening in the laboratory rather than what is happening to the patient.

Day to day biological variations in patients also relate to the quality of the extra-analytical phases, but this requires some lateral thought to fully appreciate: when defining reference intervals, the inclusion of the analytical measurement uncertainty together with the biological variations seen within and between individuals literally define the reference limits. Reference limits, defined by the biological variations within and between individuals, have become the most common method to interpret laboratory results. This cannot be underestimated as reference limits are used to determine the abnormality flags shown on a report and also to draw the clinician’s attention to changes presumed to have clinical importance.

How is biological variation, and the ability to reliably define a significant abnormality, related to the pre-analytical requesting phase? In a recent paper, Naugler and Guo introduce a new concept of using the ‘Mean Abnormal Result’ (MAR) rate as a new metric for benchmarking laboratory test requesting. 42 They observe that the MAR rate is typically about 8 to 9% across all laboratory tests requested. When physicians order many tests per request (more than 9 tests in their study), the detection of abnormalities does not increase suggesting diminishing return and waste of effort. The potential use of this metric is not only to restrict the number of tests, but also to define which tests are the most likely to be abnormal in any particular patient. The pre-test likelihood that a test will be abnormal depends on risk and disease prevalence. In our studies we have shown that some clinical indications are more likely to be associated with vitamin B12 deficiency including: ‘vegetarian’/‘macrocytic’/‘confusion’/‘dementia’, while other clinical indications including; ‘check-up’/‘fatigue’/‘tiredness’/‘lethargy’ do not increase the likelihood of an abnormal result. 43

While MAR focuses on the potential value of an abnormality in some clinical situations focused on excluding abnormality, rather than confirming an abnormality, a ‘normal’ result has clinical value. An example is when ruling out organic illness (e.g. phaeochromocytoma) so that a psychiatric diagnosis (e.g. panic disorder) can be made.

Diagnostic errors cause the majority of malpractice claims and are commonly due to either failing to request an appropriate diagnostic test, in about one half of cases, or incorrect diagnostic interpretation, in about one third of cases. 44 – 46 . It is not analytical failures of laboratory testing but extra-analytical failures which ultimately lead to failure of patient follow-up and suboptimal care. 47 We expect that correctly highlighted abnormalities will result in some clinical action. This is precisely why laboratories also set critical phoning limits, to ensure that when a patient’s wellbeing is at extreme risk, the clinician has been made aware of the abnormality in person. While continuing education of clinicians should improve the chance of diagnostic errors occurring, clinical decision support software may also be recruited to improve the requesting and interpretation of laboratory tests.

Guideline-based Clinical Decision Support for Laboratory Test Requesting

Since the value of laboratory testing primarily depends on choosing the appropriate laboratory tests, clinical decision support for laboratory test requesting needs to be focused on the clinical circumstance of each particular patient. As mentioned previously, most clinical guidelines include the appropriate laboratory tests to request in specific clinical circumstances. Several guidelines exist for the appropriate tests used in the management of ‘diabetes’, however many patients aren’t simply diabetic, they may also be: children with type 1 diabetes, or pregnant women with overt or gestational diabetes, or have comorbidities such as obesity, hypertension, dyslipidaemia or renal dysfunction with albuminuria. Each of these demographic and comorbidity factors will influence the appropriateness of laboratory testing. While simplified guidelines are desirable, each patient’s circumstance may not be as simple. Clinical pathway options for each patient may vary according to available resources and patient preferences. Clinician adherence to guidelines requires not only promotion and access to the guidelines, but also positive attitude to guidelines including an agreement on guideline content. 48 How easily a guideline can be directly applied to each of the clinician’s patients will affect the perceived applicability of the guideline.

There is an understanding that certain laboratory tests will affect what will be done to the patient depending on whether the result is normal/high/low. 49 Ideally there should be clear evidence that requesting certain laboratory tests will improve clinical outcome. Clinical guidelines are generally based on the consensus of experts who through the available evidence and/or their experience, are trusted to understand and agree that certain laboratory tests facilitate improved clinical decision making and therefore improve clinical outcome. Often there is little high level evidence and clinical guidelines depend on the eminence of the expert panel more than the evidence. 50

The development of clinical decision support tools based on clinical guidelines depends on the availability of agreed profession based guidelines as well as the tailoring of the advice to the specific circumstances of each patient. Studies are now being conducted that show how clinical decision support rules can improve test utilisation, 51 – 54 however they should ideally also consider the issue of clinical outcome. 55

Clinical Decision Support for Laboratory Test Interpretation

High quality computerised clinical decision support can increase evidence based prescription and decrease primary care prescription costs. 56 Laboratory tests that matter, or have value, are those that produce actionable results that bring a positive outcome benefit for the patient. 57 Therefore, clinical decision support for laboratory test interpretation would not stop at assisting to define health status, but also to actively encourage appropriate clinical follow-up. In fact it can be argued that the accurate definition of health status (e.g. an accurate diagnosis) is not as important as ensuring the appropriate clinical follow-up. An example is in the histological diagnosis of malignancy where the accurate definition of which type of malignancy it is, is not as important as the fact that it was completely excised. Therefore when judging interpretation of pathology reports, an inaccurate report diagnosis that leads to appropriate treatment (as for the true diagnosis) is not as bad as an accurate diagnosis that has not been translated to appropriate clinical follow-up.

Recently, the IFCC working group on interpretative commenting quality assurance (WG-ICQA) published their guideline on assuring the quality of interpretative comments in clinical chemistry. 58 These principles could be translated to all disciplines of laboratory medicine. The optimal interpretation is one that includes both optimal diagnosis as well as optimal follow-up while unsatisfactory or poor comments lead to inadequate or inappropriate follow-up.

What Should Laboratorians be Doing to Enhance the Clinical Value of Testing?

Medical laboratories have been focused on improving and maintaining analytical quality and they will continue to do so using existing quality assurance tools. The clinical value of testing also revolves around the selection of test that will beneficially influence clinical outcome and the interpretation of results so that the reports facilitate beneficial clinical actions. It is a requirement that an advisory service exists that both understands and liaises with clinicians in the selection and interpretation of tests. The fundamental requirement for laboratorians is therefore to nurture and expand the clinical communications of the medical laboratory which include face to face meetings, telephone consultations, newsletters and interpretative comments on reports.

The selection of clinically appropriate tests ideally requires knowledge of clinical purpose and knowledge of the tests available including their strengths and weaknesses. Clinical guidelines for appropriate test use should therefore always have the input of both clinicians and laboratorians. Clinical decision support for test selection should involve both clinicians and laboratorians and they should collaborate in initiatives to improve test selection.

Ensuring that laboratory results are available in a timely manner appropriate to the urgency of clinical decision making is another example of how laboratories can impact clinical outcomes through encouraging liaison on these issues.

Laboratory reports, which are often focused on reporting the results of analysis, should rather focus on facilitating beneficial clinical actions. Rather than wading through the details of analysis, reports should summarise the significant findings, their clinical implication and the possible beneficial clinical actions that might be indicated. Reports should be structured to highlight interpretation and action, particularly those clinical actions such as further testing on the existing sample (reflex testing), or repeat sampling, which the laboratory could help to facilitate.

The value of laboratory testing is primarily related to the ability of these investigations to promote actions that will improve health outcomes. The total cost of healthcare devoted to improving health outcome is a matter for each community while the proportion of cost attributable to laboratory testing depends on its contribution to promoting beneficial outcome. While collecting the evidence for these beneficial impacts has become a recent concern, the facts that laboratory tests affect clinical decision making and laboratory tests are included in clinical guidelines is undeniable. Enhancing the value of medical laboratory testing primarily relates to supporting each clinicians’ ability to request and interpret laboratory testing in a way that facilitates clinical decisions that improve health outcome.

This review was originally presented as the David Curnow Plenary Lecture at the Australasian Association of Clinical Biochemists Annual Scientific Meeting, held in conjunction with the Australian Institute of Medical Scientists, Brisbane, 13th September 2016.

Competing Interests: None declared.

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Phenotype of newly generated neurons following spinal cord injury in zebrafish , exploration of relationships between life course measures of socioeconomic status and structural brain changes linked with older life cognitive decline , high resolution analysis of the tumour microenvironment of high grade serous ovarian cancer (hgsoc) using single cell transcriptomics and quantitative histopathological examination , complications of portal hypertension: clinical studies , imaging of abdominal aortic aneurysm disease activity and implications for endovascular aneurysm repair , hallmarks of cotranslational protein complex assembly and its relationship with the dominant-negative effect , optimising islet transplantation therapy for the treatment of type 1 diabetes by targeting the liver niche with etanercept-loaded microparticles to promote the long term function of islets , developing a systematic, data-driven framework to identify, evaluate, and prioritise candidate drugs for clinical trials in motor neuron disease , investigating an arginase 1⁺ monocyte- macrophage population in driving fibrosis in chronic kidney disease. , in vivo investigation of component-specific functions of the hippo pathway , prevalence of female infertility in the uk armed forces , understanding colorectal cancer risk loci that alter transcriptional dynamics , behaviour change intervention for smokeless tobacco (st) cessation delivered by dentists in a dental setting: a feasibility study , dna methylation & its regulation in colorectal tumours , lesion reversibility in small vessel disease: understanding changes contributing to vascular dementia , effect of autologous macrophage therapy in cirrhosis in response to individual immune reparative pathways: developing a novel therapy , computational techniques to interpret the neural code underlying complex cognitive processes , identifying genomic and phenotypic risks factors for the clinical progression of depressive symptoms , investigating the essential extracellular invadolysin metalloprotease , defining novel regulators of inflammatory signalling in pancreatic cancer .

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Biomedical Science Theses and Dissertations

Theses/dissertations from 2023 2023.

Gluten Free Diet Ameliorates SI Enteropathy in IGA Deficient Mice , Ryan Albert William Ball

Aortopathies: Mechanism of Pathogenesis and Therapy , Mengistu G. Gebere

Leptin, Serotonin, and the Control of Food Intake , Nicholas David Maxwell

Targeting Macrophages in Cancer Models Using Natural Compounds , Sierra Jordan McDonald

Neurodevelopmental and Transient Impacts of Brain Kynurenic Acid Elevation and Sleep-Wake Behavior , Katherine Rentschler

Exploration Into the Relationship Between Colitis and Depression: A Potential Role for the Aryl Hydrocarbon Receptor , Kasie Lynn Roark

B-Cell-Specific MHCII Promotes Host-Microbiome Symbiosis , Mary Melissa Roland

Cardiac Imaging in Mice With Micro-Computed Tomography: An Assessment , Kyle Porter Stegmann

Theses/Dissertations from 2022 2022

Role of Epigenome in Regulation of Inflammation By AHR Ligands 2,3,7,8-Tetrachlorodibenzo-P-Dioxin and 6-Formylindolo[3,2-B] Carbazole , Alkeiver Cannon

Neurochemical, Molecular, and Behavioral Effects of Intranasal Insulin , Jennifer Marie Erichsen

Sex Differences and Potential Non-invasive Treatments for Calcific Aortic Valve Disease , Henry Pascal Helms

Decellularization Strategies of Naturally Derived Biomaterials for Tissue Engineering Applications , Julia Elizabeth Hohn

Role of AhR in the Epigenetic Regulation of Immune Cells in Lungs During Acute Respiratory Distress Syndrome , Bryan Latrell Holloman

The Submission of a Section 513(g) Request For Information , Morgan Ashley Lano

Engineering and Optimization of an AAV Based Viral Vector to Limit the In-Vitro Expression of SARS-CoV-2 Spike-Protein , Ronald Anderson Smithwick

In Vitro and in Vivo Studies of Mediator Kinase , Lili Wang

Theses/Dissertations from 2021 2021

Role of AhR Ligands in Immune Modulation to Suppress Inflammation Through the Regulation of Microrna and Gut Microbiome , Osama Azeldeen Abdulla

Role of Estrogen in Regulating Diet-Induced Obesity in Females , Ahmed Aladhami

Impact of Acetylcholine on Internal Pathways To Basal Amygdala Pyramidal Neurons , Tyler Daniel Anderson-Sieg

Pseudomyxoma Peritonei Derived Cancers: A Novel Study on Growth and Growth Suppression Utilizing Common Colorectal Cancer Agents , Raymond Kennith Bogdon

Impact of Acetylcholine on Amygdala Network Oscillations , Joshua Xavier Bratsch-Prince

Real Time Neurochemical Analysis of the Brain For Pharmacological Treatments in Mood Disorders And Neurodegeneration , Anna Marie Buchanan

Regulation of Inflammatory Processes by Tryptamine, Cannabidiol and 2,3,7,8-Tetrachlorodibenzo-P-Dioxin , Nicholas Dopkins

Study of the Effect of B-Cell-Intrinsic Mhcii Antigen Presentation on Germinal Center B Cell Evolution Using The Brainbow Mouse Model , Nia Hall

Mechanism of Therapeutic Efficacy of New Drugs in Glioblastoma , Firas Hameed Khathayer

The Effect of Low Dose Penicillin on Tumor Development in Apc Min/+ Mice , Kinsey Ann Sierra Meggett

Defining the Pathophysiology of Gut Humoral Immunodeficiency , Ahmed Dawood Mohammed

The Role PDE11A4 Signaling and Compartmentalization in Social Behavior , Kaitlyn Pilarzyk

Anatomical Correlates of Age-Related Basal Forebrain Dysfunction , Brandy Lynn Somera

A Novel Model to Study Adipose-Derived Stem Cell Differentiation , Austin N. Worden

Theses/Dissertations from 2020 2020

Molecular Mechanisms of Loss of E7 Expression in HPV16 – Transformed Human Keratinocytes , Fadi Farooq Abboodi

17 β-Estradiol and Phytoestrogens Attenuate Apoptotic Cell Death in HIV-1 Tat Exposed Primary Cortical Cultures , Sheila Marie Adams

Helicobacter’s Effects on Colitis/Colon Cancer and the Response to Indole 3-Carbinol , Rasha Raheem Abdulhamza Alkarkoushi

A Comparative Study of Cannabinoids & CB1 Receptor GI Signaling , Haley Kristen Andersen

Expansion Microscopy: A New Approach to Microscopic Evaluation , Ashley Ferri

The Role of Acute and Chronic Neuroinflammation in Depression: Uncovering the Relationship Between Histamine and Serotonin Transmission , Melinda Hersey

The Use of Natural Anthraquinone Emodin as a Primary and Complementary Therapeutic in the Treatment of Colorectal Cancer , Alexander-Jacques Theodore Sougiannis

The Effects of Super-Resolution Microscopy on Colocalization Conclusions Previously Made With Diffraction-Limited Systems in the Biomedical Sciences , Madison Emily Yemc

Theses/Dissertations from 2019 2019

Role of Epigenome and Microbiome in Cannabinoid and Aryl Hydrocarbon Receptor-Mediated Regulation of Inflammatory and Autoimmune Diseases , Zinah Zamil Al-Ghezi

Tissue-Specific Roles of Transforming Growth Factor Beta Ligands in Cardiac Outflow Tract Malformations and Calcific Aortic Valve Disease , Nadia Al-Sammarraie

Role of Epigenetic, Molecular and Cellular Pathways in the Regulation of Inflammation , William James Becker

Neurochemical and Behavioral Outcomes of Intranasal Orexin Administration in Young and Aged Animals , Coleman Blaine Calva

Interdependent Mechanisms of Stress Susceptibility , Julie Elaine Finnell

Astrocyte Sensitivity to Dopamine in Culture and Ex Vivo , Ashley L. Galloway

Three-Dimensional Plasma Cell Survival Microniche in Multiple Myeloma , Katrina A. Harmon

Role of Epigenome and Microbiome in Endocannabinoid-Mediated Regulation of Inflammation During Diet-Induced Obesity , Kathryn Miranda

Epigenetic and Purinergic Regulation of Mast Cells Mediator Release , Zahraa Abdulmohsin Mohammed

Effect of TCDD, an Environmental Contaminant, on Activation of AHR Leading to Induction of Myeloid Derived Suppressor Cells (MDSCS) and the Ability of Resveratrol, a Botanical, to Neutralize this Effect , Wurood Hantoosh Neamah

An Anatomical Basis of the Differential Cholinergic Modulation of Valence-Specific Pyramidal Neurons in the Basolateral Amygdala , Nguyen Vu

Analysis of Cellular Interactions Within a Collagen Hydrogel , Austin N. Worden

Theses/Dissertations from 2018 2018

Role of Mammary Microenvironment in Promoting Left-Right Differences in Tumor Progression, Metastasis, and Therapeutic Response , Huda Issa Atiya

Enhancements in Alginate Microencapsulation Technology & Impacts on Cell Therapy Development , Marwa Belhaj

Effect Of Resveratrol On The Development Of Eczema , Christopher Carlucci

The Nervous System And Cancers Of The Head And Neck , Christian A. Graves

Turning Up Antitumor Immunity Against Breast Cancer , Johnie Hodge

Exploring Alternative Therapeutic Interventions For The Treatment Of Leigh Syndrome , Stephanie Martin

Regulation Of Prostaglandin D2 And Angiogenesis-Related Factors From Human Skin Mast Cells By Interleukin-6 And Resveratrol , Cody Cody McHale

Advanced Clearing Methods and Imaging Techniques for Optimized Three- Dimensional Reconstruction of Dense Tissues , Caleb A. Padgett

Role Of MIR-489 In HER2 Positive Breast Cancer , Yogin Patel

Operation Of The Leica SP8 Multiphoton Confocal System Using Single Or Multiple Fluorochromes , Amy E. Rowley

Theses/Dissertations from 2017 2017

Garlic Inhibits Inflammation during Dengue Infection , Alex R. Hall

Functional Role of the Homeobox Transcription Factor Six1 in Neoplastic Transformation of Human Keratinocytes , Maria Hosseinipour

Individual Differences in Markers of Cholinergic Signaling Correlating to Fear and Extinction Learning , Grace C. Jones

The Role Of Cyclin-Dependent Kinase 8 In Vascular Disease , Desiree Leach

Succination Impairs Protein Folding and Promotes Chop Stability in the Adipocyte during Diabetes , Allison Manuel

Muscarinic Acetylcholine Receptor M1’s Impact on Fear Extinction Learning , Joshua R. McElroy

Hemodynamic Regulation Of Cardiac Valve Development , Vinal Menon

The Role Of Inflammation In Atherosclerosis , Fatma Saaoud

Synergism of Quercetin and Sodium Butyrate for Controlling Growth of Glioblastoma , Matthew Alan Taylor

Mast Cells and Lipid Cross-Talk in Skin Inflammation , Piper Alexandra Wedman

Theses/Dissertations from 2016 2016

Tumor Suppressor p53 Response To UV Light In Normal Human Keratinocyte Strains From Different Individuals , Fadi Farooq Abboodi

Vitamin D and Stress Fractures in Collegiate and Professional Athletes , Christian Michael Askew

Linking Obesity & Breast Cancer: Role Of Monocyte Chemoattractant Protein-1 And High Fat Diet-Induced Inflammation On Mammary Tumorigenesis , Taryn L. Cranford

The Identification Of The Direct And Indirect Pathways Through Which Leptin Facilitates Synaptic Plasticity In The Hippocampus , Catherine Van Doorn

Morphogenic Effects Of Dopamine In Cultured Rat Hippocampal Astrocytes , Ashley L. Galloway

Emodin Regulates Macrophage Polarization: Application In Breast Cancer Treatment , Stephen Iwanowycz

Differences In Resting-State Functional Connectivity Of Chronic Migraine, With And Without Medication Overuse Headache, And The Effectiveness Of Sphenopalatine Ganglion Block As A Treatment For Repairing Dysfunctional Connectivity. , Kaitlin Krebs

Prospective Assessment Of Health Disparities And Injury Risk Factors At Basic Combat Training At Ft. Jackson , Kristin Lescalleet

Transcriptional And Post-Transcriptional Regulation Of NRF2 In The Heart By The Deubiquitinase CYLD , Bryan J. Mathis

Regulation of Chronic and Acute Inflammatory Disease by microRNA and Microbiota , Pegah Mehrpouya-Bahrami

The Effect of Arsenic on Type 2 Diabetes and Inflammation , Kayla Penta

Factors Influencing The Collagen Fiber Angle Distribution in The Mouse Aorta , Shana Roach Watson

The Role of Epidermal Stem/Progenitor-Like Cells In HPV-Mediated Pre-Neoplastic Transformation , Yvon L. Woappi

Theses/Dissertations from 2015 2015

Extensive Genome Rearrangements of Caulobacter K31 and Genomic Diversity of type B3 Bacteriophages of Caulobacter Crescentus , Kurt Taylor Ash

Evaluating Muscle Fiber Architecture , Morgan Ashley Flahive

Characterization of STARD4 and STARD6 Proteins in Human Ovarian Tissue and Human Granulosa Cells and Cloning of Human STARD4 Transcripts , Aisha Shaaban

Cannabinoid-mediated Epigenetic Regulation of Immune Functions , Jessica Margaret Sido

The Effect of 3D Collagen Scaffolds on Regulating Cellular Responses , Chad Simmons

Theses/Dissertations from 2014 2014

Metformin Arrests Growth and Induces Apoptosis of Neuroblastoma Cells , Nadia Al-Sammarraie

Cellular and Biochemical Effects of Sparstolonin B on Endothelial Cells to Inhibit Angiogenesis , Marwa Belhaj

An Evolutionary Perspective on Infectious and Chronic Disease , John Eberth

Status Epilepticus Induced Alterations in Hippocampal Anatomy and Neurotransmission , Denise K. Grosenbaugh

The Cardio-Protective Effects of Substance P in Both Ischemia/Reperfusion and and Short-Term Hypoxia Rat Models , Shaiban Jubair


MCP-1 In Colorectal Cancer: Benefits of Exercise , Jamie Lee McClellan

Diethylstilbestrol (DES) mediates immune suppression via modulation of microRNA expression in mice , Martine Menard

Effects of cPLA-2 on the Migration and Proliferation of Human Vascular Smooth Muscle Cells and the 2-D Migratory Patterns of Tropomyosin in Femoral and Abdominal Aorta Tissue , Jaimeson Thomas Powell

The Role of MicroRNA in Staphylococcal Enterotoxin B-Induced Inflammation and Acute Lung Injury , Roshni Rao



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Dissertations / Theses on the topic 'Medical Biochemistry and Clinical Chemistry'

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Stemp, Melissa. "Biomarkers of disease : concentrations in the serum of women during natural and stimulated ovarian cycles and during early pregnancy." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2013. https://ro.ecu.edu.au/theses/865.

Woods, Nicole Natasha Brooks Lee R. "The role of biomedical knowledge in medical diagnosis by learners." *McMaster only, 2005.

Meiklejohn, Barbara A. "Ektachem evaluation /." Online version of thesis, 1985. http://hdl.handle.net/1850/9634.

Wabomba, Mukire John. "Signal and Image Processing Techniques for Environmental and Clinical Applications of Infrared Spectroscopy." Ohio University / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1040131767.

Carberry, Helen. "Semiotic analysis of clinical chemistry: for "knowledge work" in the medical sciences." Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/15809/1/Helen_Carberry_Thesis.pdf.

Carberry, Helen. "Semiotic analysis of clinical chemistry: for " knowledge work " in the medical sciences." Queensland University of Technology, 2003. http://eprints.qut.edu.au/15809/.

Bani, Rashaid Ayat H. "Clinical and Forensic Biomarkers in Human Hair." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1407256298.

Wang, Yin 1951. "Influences of membrane biophysical properties on the Metarhodopsin I to Metarhodopsin II transition in visual excitation." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/282520.

Persson, Johanna. "Hälsoundervisning : Elevers syn på hälsa inom ämnet Idrott och hälsa." Thesis, University of Kalmar, School of Human Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-2478.

Fler unga människor än någonsin är idag överviktiga och stress och stressrelaterade symptom drabbar idag allt fler unga. Därför är det viktigt att unga människor får kunskaper om hur de på bästa sätt kan ta hand om sig själva.

 Syftet med detta arbete är att undersöka hur elever som läser gymnasiets kurs Idrott och hälsa A ser på den hälsoundervisning de får.

Detta är relevant för alla som arbetar som idrott och hälsa lärare för att kunna hitta en jämkning mellan kursplan och elevernas tankar och förkunskaper.

 Genom intervjuer och fokusintervjuer kom jag fram till att eleverna vill lära sig mer om stress och hur man hanterar stress samt om kost. Eleverna tycker däremot att idrottsläraren inte är rätt person att lära ut kunskaper om tobak.

Tang, Yuanyuan. "Nitric Oxide/Peroxynitrite Imbalance Induces Adhesion of Cancer Cells to Lymphatic Endothelium - Clinical Implications for Cancer Metastasis." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1439563414.

Ozinsky, Adrian. "Post-translational processing of the low density lipoprotein receptor." Doctoral thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/26672.

Lu, Liang. "CLINICAL AND ANIMAL STUDIES OF LIPID-DERIVED PROTEIN MODIFICATIONS IN AUTISM, KIDNEY DIALYSIS, KERATITIS AND AGE-RELATED MACULAR DEGENERATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1180231149.

Barnard, Sandra H. "Amalgamation of Nucleosides and Amino Acids in Antibiotic Biosynthesis." UKnowledge, 2013. http://uknowledge.uky.edu/pharmacy_etds/20.

Borg, Mathias. "Study of the insulin-like peptide 3 in human platelets." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-21016.

The insulin-like 3 peptide is autocrine/paracrine insulin-related hormone with a size of approximately 6kDa [1]. It mediates through a leucine richG-coupled receptor named LGR8. INSL3 is mainly expressed in human Leydig cells and is directly responsible for migration of the testis during the pre-natal period in maledevelopment. [2]

INSL3 mRNA has recently been verified in human platelets whereas no mRNA has been detected for LGR8 (by Sanofi-Aventis GmbH in Frankfurt,Germany), indicating that INSL3 might be released through paracrine functions at sites of platelet adhesion and aggregation upon a vascular injury.Furthermore, has activated platelets been shown to translate essential proteins upon activation, in a term called “signal-dependent protein synthesis”.The B-Cell lymphoma-3 protein (BCL-3) is an example of such a protein [3], and there is a possibility that INSL3 might be also.

In this thesis we wanted to detect the relaxin- like peptide 3 hormone (INSL3). (Its function, location and the timeframe of its release, when/if it issecreated in stimulated platelets).The source of platelet-derived INSL3 can be found with Western blotting and Enzyme immunoassay.

Detection of the insulin-like 3 peptide in human platelets turned out to be a difficult challenge due to the small amount of INSL3 secretion uponplatelet activation; hence the total amount of INSL3 produced might be below detection limit.

Rafael, Venson. "Hollow-fibre liquid-phase microextraction : investigation into the potential use in clinical and forensic toxicology." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8697/.

Shah, Ketan. "Development of clinical biomarkers of DNA double strand breaks for cancer care." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:2e6b2595-fbbc-4fff-80e2-bec8a4d9d15e.

Alabdulwaheed, Abdulhameed. "3D-Printed Fluidic Devices and Incorporated Graphite Electrodes for Electrochemical Immunoassay of Biomarker Proteins." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3477.

English, Suzanne Elizabeth. "Within-host evolution of HIV-1 and the analysis of transmissible diversity." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:df24b49c-fb27-49a3-bd2e-3e38008e9da4.

Tian, Lei. "BIOCHEMICAL CHARACTERIZATION OF HUMAN MISMATCH RECOGNITION PROTEINS MUTSα AND MUTSβ." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/43.

Paripelly, Rammohan. "Molecular Level Interaction of Human Fibroblast Growth Factor-1 (hFGF-1) With Phloridzin." TopSCHOLAR®, 2013. http://digitalcommons.wku.edu/theses/1314.

Wallin, Olof. "Preanalytical errors in hospitals : implications for quality improvement of blood sample collection." Doctoral thesis, Umeå universitet, Institutionen för medicinsk biovetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1672.

Sayce, Andrew Cameron. "Iminosugars as dengue virus therapeutics : molecular mechanisms of action of a drug entering clinical trials." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8d4da0ce-bfa6-447d-a280-630479f898af.

Wright, Sam Mathew. "Structural and biophysical studies of RNA-dependent RNA polymerases." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:d5c2a16d-e1e2-4c22-aca5-70f72aa96853.

Beer, Nicola L. "The role of genetic variation in glucokinase and glucokinase regulatory protein in diabetes and related traits." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:87f8ea0d-9528-49fd-8f01-5f976cf9f210.

Klinac, Dragana. "The evaluation of midazolam on head injured patients in the prehospital setting." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2008. https://ro.ecu.edu.au/theses/195.

Zhou, Gang. "PURIFICATION AND CHARACTERIZATION OF BLOOD ASPIRIN HYDROLASES." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1338916020.

Källebring, Tina. "THE EXPRESSION OF THROMBOMODULIN, TISSUE FACTOR, TISSUE FACTOR PATHWAY INHIBITOR AND ENDOTHELIAL PROTEIN C RECEPTOR IN NORMAL AND IUGR PLACENTA." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6156.

The aim of this study was to examine the expression of Thrombomodulin, Tissue Factor, Tissue Factor Pathway Inhibitor and Endothelial Protein C Receptor in placenta throughout the three phases of the third trimester in the normal placenta and in IUGR placenta from full term.

Twenty-five normal placenta samples and twenty-five IUGR placenta samples were obtained and each sample was stained by immunohistochemistry using monoclonal antibodies. Each antibody was optimised for antigen retrieval method and for optimal dilution, before been applied to the test tissue.

The results showed that each of the antibodies mentioned was expressed in normal placenta and in IUGR placenta.

No significant difference could be established concerning the expression of each antibody mentioned between normal and IUGR placenta.

Sukthankar, Pinakin Ramchandra. "Biophysical characterization of branched amphiphilic peptide capsules and their potential applications in radiotherapy." Diss., Kansas State University, 2014. http://hdl.handle.net/2097/18174.

Gaentzsch, Ricarda E. G. "Establishment and maintenance of the DNA methylation pattern in the human alpha-globin cluster." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:fecf70d2-4845-4f42-b890-c163a1020eec.

Mai, Yvonne M. "Use of various health care providers and the associated clinical and humanistic outcomes in an ambulatory Medicare population." Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/265.

Pang, Chunyan. "REGULATION OF L-TYPE VOLTAGE-DEPENDNET CALCIUM CHANNELS BY THE REM GTPASE." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/656.

Lundin, Desiré. "Do the new signal transduction modulators have activity in vitro in tumor cells from ovarian carcinoma and lymphoma?" Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6158.

During the last decades, chemotherapy with cytotoxic drugs has played a significant role in cancer therapy. It’s important to develop new anticancer drugs, and drug sensitivity testing in vitro can be used to find the right diagnosis for the newly developed substances.

The aim of this study was to investigate the cytotoxic activity of the new signal transduction modulators bortezomib, gefitinib and PKC412. The well-established substances cisplatin, cytarabine, doxorubicin and vincristin were investigated for comparison.

The activity of the cytotoxic drugs was analysed in human tumor samples from patients with ovarian carcinoma (n=16) and lymphoma (n=15) by using the Fluorometric Microculture Cytotoxicity Assay (FMCA). The testing of cellular drug resistance by FMCA was accomplished successfully in 33 out of the 34 samples (97%).

The results of this study indicated that the activity of cytotoxic drugs in tumor cells obtained from patients with ovarian carcinoma and lymphoma may be detected by the FMCA. It also suggested that bortezomib and gefitinib could represent promising agents for treatment of ovarian carcinoma and that PKC412 might be of less use for patients with this diagnose.

He, Qinghao. "The Degradation of Pharmaceutical Pollutants in Wastewater Catalyzed by Chloroperoxidase and the Construction of Chloroperoxidase H105R Mutant." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2540.

Borg, Johanna. "Jämförelse av kemiinstrument och validering av referensintervall hos hund och katt." Thesis, Högskolan Kristianstad, Fakulteten för naturvetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-22058.

Sanvitale, Caroline E. "Investigation of kinase activation in fibrodysplasia ossificans progressiva." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3ac802e9-a864-4a0d-8e13-f21bcffc957d.

Lee, Hyosung. "DEVELOPMENT OF NOVEL AHR ANTAGONISTS." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/103.

Whalen, Daniel M. "Structural and functional studies of the hedgehog signalling pathway." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:ce0e765c-04f1-4a64-a67b-89204ecaa155.

Cisek, Katryna. "Rational Optimization of Small Molecules for Alzheimer’s Disease Premortem Diagnosis." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338325484.

Chitranshi, Priyanka. "Interactions of small molecules with duplex DNA and lesion containing G-quadruplex DNA." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/145.

Fierer, J. O. "Development of spontaneous isopeptide bond formation for ligation of peptide tags." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:833289ee-87cf-42f0-a66f-ca9ef9dd6420.

Lucca, Julie Ann. "ASSOCIATIONS BETWEEN ALCOHOL CONSUMPTION AND FASTING BLOOD GLUCOSE IN YOUNG ADULTS." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/1057.

Buen, Zachary. "Establishment of gas-phase thermochemical values of various small organic compounds and oligopeptides." Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/262.

Mindemark, Mirja. "The Use of Laboratory Analyses in Sweden : Quality and Cost-Effectiveness in Test Utilization." Doctoral thesis, Uppsala universitet, Klinisk kemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120554.

Williams, Jennifer Nicole. "Metal Containing Nucleosides that Function as Therapeutic and Diagnostic Agents Against Brain Cancer." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1409238775.

Lopez, Aguilar Aime. "Peptides as therapeutics." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:d893e962-5cb9-4d50-bbe1-c5183418295c.

O'Hara, Connor P. "Inhibition of Cancer Stem Cells by Glycosaminoglycan Mimetics." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5989.

Soler, Lecha Anna. "Desenvolupament de la gestió del risc al laboratori clínic. Aplicació al procés analític del Programa de Cribratge Neonatal de Catalunya." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/670019.

Söderberg, Johan. "Sources of preanalytical error in primary health care : implications for patient safety." Doctoral thesis, Umeå universitet, Klinisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-21256.

Fu, Josephine K. Y. "Functional characterization of the teleost multiple tissue (tmt) opsin family and their role in light detection." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:39bc18bb-16cb-4549-94cd-5f872daafe7e.

Chen, Bety. "Estudo dos polimorfismos das regiões hipervariáveis HV1 e HV2 do DNA mitocondrial da população brasileira aplicado à identificação humana." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-19032015-095415/.


Home > MAHE Student Work > KMCMLR

Kasturba Medical College, Mangalore Theses and Dissertations

Theses/dissertations from 2021 2021.

“The Impact of Self-Stigma of Seeking Help and Perceived Social Support on Burnout among Clinical Psychologists” , Aavrita A

The impact of self-stigma of seeking help &percieved social support on burnout among clinical psychologists. , Aavrita .

Immediate Effects of Novel Hand Rehabilitation Board on Fine Motor Skills in Children with Cerebral Palsy. , Romita Fernandes. Abraham


Comparative predictive validity of Alberta Infant Motor Scale and Infant Neurological International Battery in Low Birth Weight Infants- A Prospective Longitudinal Study. , Polisetti Siva Sai Anand

Antagonistic Asynchrony in Muscle Recruitment Pattern of Forward Reach Movement In Children With Cerebral Palsy. , Sanya Anklesaria

Muscle fatigue response of rotator cuff muscles in sitting and standing postures , Lisanne Aranha

Effectiveness of static weight bearing versus modified constraint induced movement therapy on improving hand function in hemiplegic cerebral palsy- A Randomized Clinical Trial. , Ruth Bavighar

How informed are our patients about generic medicines? – A study from coastal South India , Darshan BB

Morphological variants of the human spleen, a cadaveric study , Murlimanju BV

Association between cervical breast cancer and Diabtetes mellitus among women seeking health care in tertiary hospitals od south India: A cross sectional study , Pratik Kumar Chatterjee

Carcinoma Breast in among Women with Diabetes Mellitus: A Case Control Study , Pratik Kumar Chatterjee

Perception of Empathy among medical students: A cross sectional study , Pratik Kumar Chatterjee


Study of outcome of Ponseti technique of management for idiopathic clubfoot in a tertiary center in south India , Lulu Damsas

Comparative study of emotional labour &burnout on life satisfaction among school teachers across different educational settings , Meghana Dharampalan

“Comparative Study of Emotional Labor and Burnout on Life Satisfaction Among School Teachers Across Different Educational Settings” , Meghana V. Dharmapalan

“Relationship Between Sexual Fantasy, Sexual Communication, Personality Traits and Sexual Satisfaction in Married Individuals” , Rhea Dhir

Comparing the efficacy of USG guided supraclavicular brachial plexus block with or without intercostobrachial nerve block for forearm surgeries – an observational study , DIKSHA D’MELLO

Does Quality of Sitting influence Functional Mobility in Cerebral Palsy? A cross-sectional study , Kaiorisa N. Doctor

Factors effecting gait velocity in osteoarthritis knee-An observational study. , Lisha Gretal D’silva

Effect of Inspiratory Muscle Training on Pulmonary Function, Functional Capacity, Quality Of Life And Length Of Stay in individuals undergoing Cardiac Surgery , Fiona Verdine Dsouza

Relationship of Academic Resilience with Self-Efficacy, and Perceived Social Support; Among Civil Service Aspirants , Neha Eldho


Comparison of efficacy of two different bolus doses of norepinephrine as prophylac-tic to prevent post-spinal hypotension during elective caesarean section , PRANATHI GARAPATI

Trends in Frailty and its Associated factors in Community Dwelling Elderly Indian Population during COVID-19 Pandemic- A Prospective Analytical Study , Karan Gautam

Speech Sound acquisition in some south Indian Dravidian languages: A systematic review , Jesica George

Comparison of Femoral nerve block with Dexmedetomidine and Adductor canal block with Dexmedetomidine for postoperative analgesia for Total Knee Arthroplasty . , NEHA GEORGE

Assessment Of Cardiovascular Risk Factors In Patients With Osteoarthritis Knee , Sagar Goel

Effectiveness of Intermittent Cervical Traction with and without Neural Mobilization in Discogenic Cervical Radiculopathy , Aditi Goyal

Study of maternal and cord blood vitamin B12 levels with anthropometry in term neonates born to normal and malnourished mothers: a hospital based cross sectional study , Sugapradha a. GR

Development of a Questionnaire to Determine the Intervention and Service Delivery Practices of Speech-Language Pathologists for Children with Speech Sound Disorders in India , Shaily Gupta

Relationship between Physical Activity, Objective Sleep Parameters and Circadian Rhythm in Patients with Head and Neck Cancer receiving Chemoradiotherapy- A Longitudinal Study , Rachita Gururaj

“Emotional Contagion, Perceived Stress and Coping Strategies Among Nurses” , Saumya Hariharan

Assessment of knowledge and belief about stuttering among undergraduate medical students , Anushree Harihar

Association of serum lipid levels and other systemic risk factors with retinal hard exudates in diabetic retinopathy patients. , Harshita Mukesh Hiran

Assessment of risk of Diabetes Mellitus by using Indian Diabetes Risk Score among Housekeeping staff , Ramesh Holla

“Emotional Intelligence, Self-compassion, and Life-Satisfaction In Clinical Psychologists” , Vania Jacob


Study to assess the role of doppler ultrasound in evaluation of arteriovenous hemodialysis fistula and the complications of hemodialysis access , Ishank Jain

Relationship between burnout compassion fatigue, work environment & mindfulness in medical residents , Pranay Javeri

“Relationship Between Burnout, Compassion Fatigue, Work Environment and Mindfulness in Medical Residents” , Pranay Harichandra Javeri

“Dating Anxiety in Emerging Adults” , Jisha V. Jayaprakash

“Relationship Between Tolerance for Disagreement and Mindfulness in Married Males and Married Females” , Jahnavi Jha

Antibiotic usage and susceptibility patterns in Uncomplicated UTI in a Tertiary Hospital in South India , Christy John

Association of bed rise difficulty scale with trunk impairment and functional scales among stroke patients , Leena G. John

Is there a correlation between Pediatric Berg Balance Scale and Centre of Pressure Excursion measured through Dual Axis Static Force Plate™ to assess Balance in Children with Spastic Cerebral Palsy and Typically Developing? , Niharika Joshi

Comparison of Sensory Processing Responses in Cerebral Palsy Subtypes and Typically Developing Children (7-36 months): A Cross Sectional Study. , Archana Antony K

‘A study on the Role of Learned Helplessness, Selfefficacy and Perceived Social Support in Determining Resilience in Parents of Children with Neurodevelopmental Disorders’ , Benaisha Khurshed Katrak

A study of correlation of maternal serum zinc levels with breast milk and cord blood of late preterm neonates , Rashmi Katti

Correlation of histopathology and direct immunofluorescence findings in clinically diagnosed prurigo nodularis , Haritha K

Difference in proximal femur loading due to muscle activity during partial weight bearing and NWB standing- A cross-sectional study. , Smital Kshirsagar

Effect of Sesamol on neurobiochemical changes in diet induced (DIO) obesity model of Zebra fish (Danio rerio) , Rashmii K.S.

Importance of integration of medical ethics with undergraduate medical curriculum- Instructors and student’s perspectives. , Rashmii K.S.

Long-term potentiation (LTP): A simple yet powerful cellular process in learning and memory , Rashmii K.S.

Parkinson's Disease Overview: Alternative Potential Curcumin Treatment, Current Treatment and Prevalence Among Ethnic Groups , Rashmii K.S.

Smart brain of India vs. tricky drugs , Rashmii K.S.

The Role of Professionalism and Ethics Training: Instructor’s and Student’s perspectives in a medical College , Rashmii K.S.

Violence Against Doctors: A Qualitative Study On This Rising Predicament , Rashmii K.S.

Morphometric study of the gracilis muscle and its pedicles , Chettiar Ganesh Kumar

Comparative study of bed side tests to assess difficult airway in paediatric patients , S.Abinandha Kumar

Euphorbia thymifolia (Linn.)- A review on ethno pharmacological properties , Vasavi Kumblekar


‘Feminist Identity, Socio-cultural Attitude Towards Appearance, and Body Images issues in Emerging Adult Women’ , Sheena Lonappan

A novel approach to quantify the Dynamic Windlass Mechanism , Ishita Mahajan


Cognitive abilities among employed and unemployed middle-aged women – a systematic review , Aswini M

‘Emotional Intelligence, Job Satisfaction and Psychological Well-being Among Nurses’ , Chetna M


“Effect of Sensation Seeking and Anxious Traits on Suicidal Ideation Among Adults by Birth Order” , Haripriya G. M

Clinical & radiological assessment of intertrochanteric fractures treated with PFN A2 , Harish M

Effect of a home-based pulmonary rehabilitation programme on respiratory function, functional capacity, and quality of life in patients with chronic obstructive pulmonary disease , Vaibhavi Mhatre

Profiling Communication Characteristics of Individuals with Acquired Neuro-communication Disorder in a Tertiary Care Setup , Nikita Subudhi M

Relationship between weight bearing symmetry, trunk control and fear of fall amongst subjects with stroke: A cross sectional study , VIVIAN NEHAL MONIS

Lower extremity muscle recruitment pattern during sit to stand transfer in children with cerebral palsy as compared to typically developing children- a cross sectional study. , Kiran P. Nadgauda

Knowledge, attitudes and practices of Indian classical singers towards vocal healthcare , Raveena Muralidharan Nair

"Perspectives of Indian Speech Language Pathologists on Adolescent Language Assessment" , Rohana Muralidharan Nair

Effect Of Yoga On Perceived Stress And Pulmonary Function In High Stressed Postmenopausal Women , Vinodini NA

Refractory errors, blood groups & diabetes mellitus: A corrleative study in south Indian population , Vinodini NA

Comparison of Functional outcomes for displaced extra-articular distal radius fractures managed by Conservative versus Operative methods: A Prospective cohort study , Muhammed Ehsan Nazeer


Assessment of attitude among public towards stuttering in a coastal city of Southern Karnataka , Prithvi N

"Severity assessment of acute pancreatitis using ct severity index and modified ct severity index: association with clinical outcomes and ranson’s criteria. " , GEETANJALI PARMAR

“The Effect of Culture Shock on Adjustment and Psychological Wellbeing Among College Going Students” , Akanksha Patra

‘Effect of Religiosity on Attitude Towards Euthanasia in Medical Students’ , Sumedha Pawar

Development Of A Questionnaire To Determine The Clinical Assessment Practices Of Speech-Language Pathologists For Children With Speech Sound Disorders In India , Prasila Elsa Philip

Correlation of oxidised LDL with oxidant and antioxidant enzymes in subjects with elevated LDL levels , Pooja p

Association of emotional intelligence of primigravida mothers with breastfeeding self efficacy in the early postpartum period and exclusive breastfeeding rates up to 6 months. , Priyanka Reddy p

Morphometric study of the Sartorius muscle and its vascular pedicles , M.D. Prameela

Comparison of the analgesic duration using ultrasound guided popliteal sciatic nerve block between diabetics with neuropathy and non-diabetics without neuropathy , GANESH PRASAD

Early follicular and Mid-luteal phase associated changes in Lower extremity Muscle strength , length and Agility in amateur female athletes – a Prospective Analytical study , Vishnu Priya

Assessment of mobile device based educational intervention on breastfeeding technique in multigravida mothers and its effect on early infant feeding pattern- A randomized controlled trial. , Keerthi Raj


Correlation of Histopathology and Direct Immunofluorescence: Findings in clinically diagnosed Prurigo nodularis in a Tertiary care hospital , Haritha Reddy


Assessment of the acceptable length of Right internal jugular central venous catheters. , Nivedhitha R



Profiling selected speech characteristics in individuals with Chronic Cough , Nawal Palakkal Sathar

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    The digital thesis deposit has been a graduation requirement since 2006. Starting in 2012, alumni of the Yale School of Medicine were invited to participate in the YMTDL project by granting scanning and hosting permission to the Cushing/Whitney Medical Library, which digitized the Library's print copy of their thesis or dissertation.

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    PDF. Role of Long Noncoding RNAs in Diabetic Complications, Anu Alice Thomas. PDF. Effect of Estrogen and Glucocorticoid Signaling on Th2 cells - Implications for Severe Asthma, Meerah Vijeyakumaran. Theses/Dissertations from 2017 PDF. CRISPR Screen for Identification of Kinases that Mediate Prostate Cancer Cell Invasion, Hamad Aldhafeeri. PDF

  8. PDF Laboratory Medicine in Sub-Saharan Africa: Strengthening Systems for

    MAS ETH D&C Thesis on Development Policy Jennifer Brown 8 4 Background 4.1 The Role of Medical Laboratories in Global and Public Health Laboratory medicine fulfils multiple functions that are relevant to all levels of public health. At the individual level, medical laboratories enable the detection and diagnosis of disease, as well as the

  9. PDF Patients satisfaction and quality of clinical laboratory services

    46 Medical laboratory services are an essential component of strong national health 47 systems. Laboratory diagnosis plays a crucial role for effective clinical management 48. and control of major diseases of public health importance [1]. This requires quality 49 diagnostic services to be available and properly utilized at different levels, and ...

  10. Clinical Laboratory Management

    CA ; editors, Paul Bachner, Department of Pathology & Laboratory Medicine, University of Kentucky Chandler Medical Center, Lexington, KY [and eight others]. — 2nd edition. pages cm Includes bibliographical references and index. ISBN 978-1-55581-727-5 — ISBN 978-1-55581-728-2 (e-ISBN) 1. Medical laboratories— Administration. 2.

  11. (PDF) Addis Ababa University College of Health Sciences School of

    By: Zerihun Woldesenbet Advisors: Kassu Desta (MSc, PhD candidate) : Aster Tsegaye (MSc, PhD) : Merertu Temesgen(MD, Pediatrician) A research thesis submitted to the Department of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, Addis Ababa University, in partial fulfillment of Master of Science Degree ...

  12. 9833 PDFs

    Young-Soo Yoon. Dong-Joo Kim. Urea is an essential biomarker for the diagnosis of healthy kidneys because urea, a protein metabolite, is formed by the function of kidneys and is excreted into the ...

  13. PDF Guidelines for Master of Arts in Medical Sciences Thesis Preparation

    A Master's thesis project is to be well-conceived and of modest scope. The research project may involve library research alone, a laboratory research project alone, or may be a combination of library and laboratory research. The First Reader for the MAMS thesis must be a faculty member of the Division of Graduate Medical Sciences (GMS) at ...


    The student must develop a research proposal and supervisory team comprised of the project mentor and >2 MD/MHS committee members that operates similarly to a PhD dissertation committee. This plan and its members must be approved by the Office of Student Research and the MD/MHS Advisory Committee.

  15. Dissertations / Theses: 'Medical Laboratory'

    Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles. Consult the top 50 dissertations / theses for your research on the topic 'Medical Laboratory.'. Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the ...

  16. Enhancing the Clinical Value of Medical Laboratory Testing

    Introduction. Value is often expressed in terms of "quality, clinical efficacy and effectiveness, patient centre-edness, patient satisfaction, timeliness, clinical efficiency, cost effectiveness, productivity affordability and cost". 1 Laboratory value should ideally be judged in a manner consistent with the main goals of a health system which include disease prevention, early detection ...

  17. Edinburgh Medical School thesis and dissertation collection

    Complications of portal hypertension: clinical studies . Dunne, Philip D. J. (The University of Edinburgh, 2024-03-28) INTRODUCTION: With over 1.32 million global liver cirrhosis related deaths annually, the burden of liver disease is still rising, predominantly due to alcohol and the metabolic syndrome.

  18. (PDF) Patients' (Clients) Satisfaction with Medical Laboratory Services

    Patients' (clients/customer) services and satisfaction in Medical Laboratory Services and general healthcare is one of the twelve (12) quality essentials of Total Quality Management System (TQMS ...

  19. Dissertations / Theses: 'Medical laboratory technology'

    Consult the top 46 dissertations / theses for your research on the topic 'Medical laboratory technology.'. Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard ...

  20. Biomedical Science Theses and Dissertations

    PDF. Neurodevelopmental and Transient Impacts of Brain Kynurenic Acid Elevation and Sleep-Wake Behavior, Katherine Rentschler. PDF. Exploration Into the Relationship Between Colitis and Depression: A Potential Role for the Aryl Hydrocarbon Receptor, Kasie Lynn Roark. PDF. B-Cell-Specific MHCII Promotes Host-Microbiome Symbiosis, Mary Melissa ...

  21. (PDF) Thesis and Antithesis of Infertility in Nigeria: A Review and

    Currently, scoping reviews examining the cultural and religious beliefs of infertility and its implication on Medical Laboratory Science practice are depleted. This paper closes the gaps in this ...

  22. PDF Biomedical Laboratory Diagnostics Graduate Student Handbook

    Certification as a medical laboratory scientist (MLS or equivalent) is preferred but not required. Scholastic record, experience, personal qualifications and career goals are taken into ... There are two tracks for the Master of Science degree in Clinical Laboratory Sciences, Plan A (with thesis) or Plan B (without thesis). The student's ...

  23. Dissertations / Theses: 'Medical Biochemistry and Clinical ...

    Video (online) Consult the top 50 dissertations / theses for your research on the topic 'Medical Biochemistry and Clinical Chemistry.'. Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you ...

  24. Kasturba Medical College, Mangalore Theses and Dissertations

    PDF. Perception of Empathy among medical students: A cross sectional study, Pratik Kumar Chatterjee. PDF. CLINICOMYCOLOGICAL PROFILE OF DERMATOPHYTOSIS IN A TERTIARY CARE HOSPITAL IN SOUTH INDIA, Adyashree Dalai. PDF. Study of outcome of Ponseti technique of management for idiopathic clubfoot in a tertiary center in south India, Lulu Damsas. PDF

  25. April 8, 2024 Regulation of Laboratory-Developed Tests: Proposed Rule

    laboratory and the IVD is not distributed outside that laboratory. In this case, laboratories would have to comply only with certain QS requirements, for example, design controls (21 C.F.R. §820.30), records requirements (21 C.F.R. Part 820, Subpart M), and purchasing controls (21 C.F.R. §820.50), among others. 4.